Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles

ObjectiveTo appraise the fertilization rate as a predictive factor for cumulative live birth (CLBR).DesignMulticenter retrospective cohort study.SettingTen in vitro clinics, whose data were collected and processed by assisted reproductive technology (ART) Italian National Registry.Patient(s)7,968 couples undergoing 9,394 complete intracytoplasmic sperm injection cycles.Intervention(s)None.Main Outcome Measure(s)The primary outcome measure was CLBR association with intervals (<65%—group 1; 65%–80%—group 2; >80%—group 3). Further stratification performed on basis of maternal age (<34, 35–38, 39–42 years) number retrieved oocytes (5–7, 8–10, > 10 oocytes).Result(s)The progressively higher relation to groups 1, 2, 3 (20.1%, 34.7%, 41.3%, respectively). The recovered oocytes, embryo per cycle, pregnancy followed same trend. decrease increasing significantly correlated all groups. Multivariate logistic regression analysis showed independently associated CLBR.Conclusion(s)The present indicated positive between CLBR, suggesting clinical relevance this parameter its adoption key performance indicator. To (CLBR). Multicenter study. Ten Registry. 7,968 cycles. None. oocytes). CLBR.